anesthetic effects of adding intrathecal neostigmine or magnesium sulphate to bupivacaine in patients under lower extremities surgeries

normal 0 false false false en-us x-none ar-sa background: regional anesthesia is widely used to perform different surgical procedures including those performed on the extremities . in this study, the anesthetic effects of adding intrathecal neostigmine or magnesium sulphate to bupivacaine in patients under lower extremities surgeries were assessed. materials and methods: in this double-blind randomized clinical trial, 90 patients, candidate for lower extremities surgeries in a training hospital, were recruited. the patients with asa class i and ii aging from 20 to 65 years between 2009 and 2010 were evaluated. the selected patients were randomly assigned to receive either bupivacaine alone (group a, n=30), or bupivacaine plus magnesium sulphate 50% (group b, n=30), or bupivacaine plus neostigmine (group c, n=30). then sensory and motor onset and complete block and the time of recovery were measured. results: the sensory block onset time were 3.03±0.981 in group a, 3.90±2.71 in group b and 3.7±1.08 in group c and knee flexion time were not significantly different among the three groups ( p > 0.05), whereas the time to complete motor block was significantly longer in group c and motor recovery time were significantly different between groups ( p =0.001). conclusions: according to the obtained results, it may be concluded that magnesium sulphate is a safe and effective adjuvant for increasing the onset time of motor block .